Genetic Variation On Drug Response

According to Waleed Alabsi, the differences in the genetic makeup in individuals affects how the body reacts to a drug. Pharmaco genetics refers to the study of the genetic differences in response to drugs. Due to their genetic

According to Waleed Alabsi, the differences in the genetic makeup in individuals affects how the body reacts to a drug. Pharmaco genetics refers to the study of the genetic differences in response to drugs. Due to their genetic makeup, some people metabolize drugs slowly resulting in the drug accumulating in the body causing toxicity. Other people metabolize drugs quickly such that after they take a dose, the drug levels in the blood never become high enough for the drug to become effective.

In half the population of people in the United States, the liver enzyme that metabolizes certain drugs works slowly. Such people are known as slow acetylators. In about 1 of 1500 people, the blood enzyme that inactivates drugs such as succinylcholine is at low levels. If succinylcholine is not rapidly inactivated, it can prolong muscle relaxation making the patient not breathe on their own after surgery.

Waleed Alabsi says that there is an estimated 10% of black me and a fewer percentage of black women that have a deficiency of an enzyme that protects red blood cells from certain toxic chemicals. In this population, some drugs such as chloroquine destroy red blood cells causing hemolytic anemia.

Another 1 of 20,000 people have a genetic defect that makes their muscles to be overly sensitive to certain inhaled anesthetics such as isoflurane, halothane, and sevoflurane. When given one of these anesthetics with a muscle relaxant, a life-threatening disorder known as malignant hyperthermia develops which causes high fever, stiffening of the muscles, and low blood pressure.

Genes affect how well drugs work:

By understanding how genetic differences affect drug responses, the GENELEX SYSTEM can be able to provide a more personalized approach to selecting the right medication for the patient. This kind of personalized treatment is called precision medicine and is increasingly becoming common.

Genes influence how well your liver breaks down the medicine:

According to Waleed Alabsi, the GENELEX tests done on genetic variation, look into variations in the genes that contain instructions for making liver enzymes that metabolize drugs.

Drugs that are inactive form, meaning that the drug has an immediate effect on the body, are made inactive in the liver enabling the body to discard it. When the liver enzyme that is supposed to break down a drug does not work well due to a genetic variation, the body will not be able to get rid of the drug effectively. This can cause high levels of the drug in the body leading to serious side effects.

Other drugs are taken in an inactive form and are broken down in the liver into their active form. When the enzyme responsible for converting the drug into its active form does not work properly dor to a genetic variation, the medication won’t be able to function.

These differences in how enzymes metabolize drugs, Waleed Alabsi shows that this means that people need different doses of a drug to achieve the same effect.

Use of gene variations to choose the right medication:

Children suffering from Leukemia are usually tested for gene variations for the enzyme that breaks down drugs called thiopurines by the GENELEX SYSTEM commonly used to treat childhood leukemia. Some genetic variations, require the patient to be administered with a smaller dose for the same effectiveness.

When GENELEX tests reveal that the enzyme does not work, Waleed Alabsi recommends that they are administered one-tenth of the normal dosage. This fraction of the medication gives the same benefits as someone whose enzymes are functioning normally and is provided with 10 times the dosage because their body metabolizes the drug effectively. For medications that are converted into an active form in the liver, genetic variations can mean that a person needs a different kind of drug entirely.

Pharmacogenetic testing is only used to find out a person’s drug response to a specific medicine. Waleed Alabsi advocate for genetic tests to help diagnose diseases or potential risk of disease, identify a family relationship

Pharmacogenetics refers to the study of genetic variability that causes varied individual responses to medications. It analyzes the genes that produce specific drug targets or enzymes that metabolize a medication or are associated with immune response providing the healthcare provider with critical information to plan the patient’s treatment. The decision about which drug is to be prescribed may also be influenced by other drugs that the patient is taking.

Waleed Alabsi Group has introduced the Genelex System which is a Certified lab for clinical improvements. Patients respond differently to the same medications or experience different side effects. The difference in response can be due to inherited genes. Our unique genetic makeup and individual response may mean that a drug that is effective for one patient may be less effective for another.

Enzymes are used to metabolize drugs. An active drug may be made inactive through metabolism. An active drug may be made more active through metabolism. The biggest challenge in drug therapy is ensuring that the active form of a drug stays around long enough to work. Some patients have variable enzyme action making them metabolize the drug too quickly, too slowly, or not at all affecting the effectiveness of the drugs. No matter what your genetic makeup is the Genelex System by the Waleed Alabsi group will facilitate better health care for you. 

What is it used for?

Pharmacogenetic testing may be used to:

  1. Find out whether a certain medicine can work and be effective
  2. Find out the best treatment dosage
  3. Predict whether you will get serious side effects

What happens during a pharmacogenetic test?

The testing is usually done on blood or saliva. For a blood test, a needle is used by your health care professional to take a blood sample from a vein in your arm. A small amount of blood is collected into a test tube or vial after the needle is inserted.

For a saliva test, your health care provider you instructions on how to provide your sample.

What to do when preparing for the Pharmacogenetic test?

A patient is not required to do much preparation for a blood test. In the case of a saliva test, you should not drink, eat, or smoke 30 minutes before the test. Waleed Alabsi‘sgroup aims at performing pharmacogenetic testing and the use of medications to enhance medical care.

Are there any risks to the test?

There is minimal risk to having a blood test done. You may experience slight pain or bruise at the spot where the needle is injected but the symptoms do not last. There is no risk in having a saliva test done.

What do the results mean?

If the test was conducted before starting a treatment, it can show whether the medication will be effective and/or if you are at risk of serious side effects. Tests for certain drugs that are used to treat HIV and epilepsy can show whether you are at risk of getting life-threatening side effects.

Tests that are conducted before and while you are on treatment help your healthcare provider figure out the right drug treatment. Waleed Alabsi group through their CEO provides a training program to clinical officers to help them get acquainted with the Genelex System in the quest to offer personalized patient care.

What else do I need to know about pharmacogenetic testing?

Pharmacogenetic testing is only used to find out a person’s drug response to a specific medicine. Waleed Alabsi advocate for genetic tests to help diagnose diseases or potential risk of disease, identify a family relationship, or identify someone in a criminal investigation.

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